High-Protein Pizza Breakfast Casserole

Featured in: Oven-Finished Recipes

This satisfying morning dish combines a unique Greek yogurt dough base with a protein-packed egg topping. The crust comes together quickly with just flour, baking powder, and yogurt, creating a sturdy foundation for the fluffy egg layer. Turkey pepperoni adds classic pizza flavor while keeping things lean, and the duo of mozzarella and cheddar creates that irresistible golden, bubbly finish. Each serving delivers 22 grams of protein, making it an ideal choice for starting your day strong or fueling up after a workout.

Updated on Thu, 12 Feb 2026 10:40:58 GMT
Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. Save
Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. | petitskillet.com

Remember the days when breakfast meant a hurried slice of toast or a simple bowl of cereal? This High-Protein Pizza Breakfast Casserole changes everything. Combining the comforting flavors of pizza with the protein-packed goodness of a breakfast casserole, this dish transforms morning meals into something truly special. The Greek yogurt dough creates a tender, satisfying base that's miles better than regular pizza crust for breakfast purposes—lighter yet substantial enough to start your day right.

Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. Save
Freshly baked High-Protein Pizza Breakfast Casserole topped with golden melted mozzarella and savory turkey pepperoni slices. | petitskillet.com

What's for Dinner Tonight? 🤔

Stop stressing. Get 10 fast recipes that actually work on busy nights.

Free. No spam. Just easy meals.

The magic of this recipe lies in its clever fusion of breakfast and pizza elements. The Greek yogurt dough requires no yeast or proofing time, making this dish accessible even on busy mornings. While it bakes, your kitchen fills with the irresistible aroma of melting cheese and savory spices, drawing everyone to the table with eager anticipation. This casserole represents the best of both worlds—familiar comfort food reimagined as a nutritious start to your day.

Ingredients

Tired of Takeout? 🥡

Get 10 meals you can make faster than delivery arrives. Seriously.

One email. No spam. Unsubscribe anytime.

  • For the Greek Yogurt Dough: 1 ½ cups (180 g) all-purpose flour, 2 teaspoons baking powder, ½ teaspoon salt, 1 cup (240 g) plain Greek yogurt (nonfat or 2%)
  • For the Toppings: 8 large eggs, ½ cup (120 ml) low-fat milk, 1 cup (100 g) shredded part-skim mozzarella cheese, ½ cup (50 g) shredded reduced-fat cheddar cheese, ½ cup (60 g) turkey pepperoni slices, ½ teaspoon dried oregano, ½ teaspoon garlic powder, ¼ teaspoon black pepper, 2 tablespoons chopped fresh parsley (optional)

Instructions

Prepare the oven and pan
Preheat your oven to 375°F (190°C). Lightly grease a 9x13-inch (23x33 cm) sheet pan or casserole dish.
Make the yogurt dough
In a medium bowl, whisk together the flour, baking powder, and salt. Add the Greek yogurt and mix with a spoon until a shaggy dough forms. Knead briefly until smooth.
Form the crust
Press the dough evenly into the prepared pan, forming a thin base.
Prepare the egg mixture
In a large bowl, whisk together the eggs, milk, oregano, garlic powder, and black pepper until well combined.
Assemble the casserole
Pour the egg mixture evenly over the dough base. Sprinkle both cheeses over the eggs. Top with turkey pepperoni slices.
Bake to perfection
Bake for 20–25 minutes, or until the eggs are set and the cheese is golden and bubbly.
Finish and serve
Let cool for 5 minutes, then garnish with fresh parsley if desired. Slice and serve warm.

Zusatztipps für die Zubereitung

Don't overwork the yogurt dough—mix just until combined to keep it tender. If the dough feels too sticky, add a little more flour, one tablespoon at a time. The key to a perfect texture is pressing the dough into a thin, even layer. For meal prep, allow the casserole to cool completely before cutting into portions and storing in airtight containers in the refrigerator for up to 4 days.

Still Scrolling? You'll Love This 👇

Our best 20-minute dinners in one free pack — tried and tested by thousands.

Trusted by 10,000+ home cooks.

Varianten und Anpassungen

Create a vegetarian version by omitting the turkey pepperoni and adding sautéed mushrooms, bell peppers, and spinach. For a gluten-free option, substitute the all-purpose flour with a 1:1 gluten-free flour blend that contains xanthan gum. Try a Mediterranean twist by adding crumbled feta cheese, chopped olives, and sun-dried tomatoes. For spicy food lovers, incorporate diced jalapeños or a sprinkle of red pepper flakes to the egg mixture.

Serviervorschläge

This versatile casserole pairs beautifully with fresh fruit for a complete breakfast. For brunch, serve alongside a simple green salad dressed with lemon vinaigrette. A small bowl of warm marinara sauce makes an excellent dipping option for those who enjoy extra pizza flavor. For an extra-special weekend breakfast, top each serving with a dollop of Greek yogurt and a sprinkle of fresh herbs.

Sliced serving of High-Protein Pizza Breakfast Casserole revealing fluffy eggs and a soft Greek yogurt crust on a rustic plate. Save
Sliced serving of High-Protein Pizza Breakfast Casserole revealing fluffy eggs and a soft Greek yogurt crust on a rustic plate. | petitskillet.com

From rushed weekday mornings to leisurely weekend brunches, this High-Protein Pizza Breakfast Casserole bridges the gap between convenience and comfort. It reminds us that breakfast doesn't have to be boring or nutritionally empty—it can be both indulgent and nourishing. The next time you find yourself in a breakfast rut or need to feed a hungry crowd, remember this versatile dish that brings together the best of pizza flavors with the protein-packed ingredients of a hearty breakfast. Your taste buds—and your body—will thank you.

Recipe Q&A

Can I make this ahead of time?

Absolutely. This dish reheats beautifully and can be stored in the refrigerator for up to 4 days. Simply slice into portions and reheat in the microwave for 2-3 minutes or warm in a 350°F oven until heated through.

Can I freeze this casserole?

Yes, freeze individual slices or the entire dish. Wrap tightly in plastic wrap and foil, then freeze for up to 3 months. Thaw overnight in the refrigerator before reheating.

What can I substitute for the Greek yogurt?

Sour cream works well as a 1:1 substitute. For a dairy-free option, try plain coconut yogurt, though the dough texture may vary slightly.

Can I add vegetables to this?

Certainly. Diced bell peppers, mushrooms, spinach, or onions can be added to the egg mixture before baking. Sauté watery vegetables like mushrooms first to prevent excess moisture.

Is this suitable for meal prep?

Perfect for meal prep. The high protein content makes it ideal for grab-and-go breakfasts throughout the week. Portion into individual containers for easy reheating.

Can I use regular pepperoni instead of turkey?

Yes, regular pepperoni works fine. Keep in mind it has more fat and calories, so the nutritional information will vary slightly.

20-Minute Dinner Pack — Free Download 📥

10 recipes, 1 shopping list. Everything you need for a week of easy dinners.

Instant access. No signup hassle.

High-Protein Pizza Breakfast Casserole

Savory morning bake with protein-rich Greek yogurt crust, eggs, pepperoni, and bubbly cheese.

Prep Duration
20 minutes
Cooking Duration
25 minutes
Total Duration
45 minutes
Recipe By Ellis Carlson


Skill Level Easy

Cuisine American

Serves 6 Portions

Diet Info None specified

What You Need

Greek Yogurt Dough

01 1.5 cups all-purpose flour
02 2 teaspoons baking powder
03 0.5 teaspoon salt
04 1 cup plain Greek yogurt, nonfat or 2%

Toppings

01 8 large eggs
02 0.5 cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 0.5 cup shredded reduced-fat cheddar cheese
05 0.5 cup turkey pepperoni slices
06 0.5 teaspoon dried oregano
07 0.5 teaspoon garlic powder
08 0.25 teaspoon black pepper
09 2 tablespoons chopped fresh parsley, optional

How To Make It

Step 01

Prepare Baking Pan: Preheat oven to 375°F. Lightly grease a 9x13-inch sheet pan or casserole dish.

Step 02

Mix Dough Base: In a medium bowl, whisk together flour, baking powder, and salt. Add Greek yogurt and mix with a spoon until shaggy dough forms. Knead briefly until smooth.

Step 03

Form Dough Layer: Press dough evenly into prepared pan, forming a thin base that covers the entire surface.

Step 04

Prepare Egg Mixture: In a large bowl, whisk together eggs, milk, oregano, garlic powder, and black pepper until well combined.

Step 05

Add Egg Mixture: Pour egg mixture evenly over the dough base.

Step 06

Top with Cheese and Pepperoni: Sprinkle both mozzarella and cheddar cheeses over the eggs. Distribute turkey pepperoni slices across the top.

Step 07

Bake Casserole: Bake for 20 to 25 minutes, or until eggs are set and cheese is golden and bubbly.

Step 08

Cool and Serve: Let cool for 5 minutes. Garnish with fresh parsley if desired. Slice and serve warm.

You Just Made Something Great 👏

Want more like this? Get my best easy recipes — free, straight to your inbox.

Join 10,000+ home cooks. No spam.

Equipment Needed

  • 9x13-inch sheet pan or casserole dish
  • Mixing bowls
  • Whisk
  • Measuring cups and spoons
  • Knife and cutting board

Allergy Info

Look through each ingredient for allergen concerns, and please ask a medical expert if you've any questions.
  • Contains wheat gluten
  • Contains eggs
  • Contains milk dairy
  • Check turkey pepperoni and cheese labels for additional potential allergens

Nutrition Details (for each serve)

Use these nutrition details as a rough guide—they're not medical advice.
  • Energy: 260
  • Fats: 10 g
  • Carbohydrates: 19 g
  • Proteins: 22 g

Cooking Shouldn't Be Hard ❤️

Get a free recipe pack that makes weeknight dinners effortless. Real food, real fast.

Free forever. Unsubscribe anytime.