High-Protein Pizza Breakfast Casserole

Featured in: Oven-Finished Recipes

This hearty breakfast casserole transforms pizza flavors into a nutritious morning meal. The foundation is a simple Greek yogurt dough, rolled out and topped with pizza sauce, then layered with a fluffy egg custard, melted mozzarella and cheddar, turkey pepperoni, and colorful vegetables. Each serving delivers 20g of protein, making it ideal for fueling your day or prepping ahead for busy mornings. The entire dish comes together in just 45 minutes, with a golden, bubbly finish that's both satisfying and guilt-free.

Updated on Mon, 09 Feb 2026 08:09:02 GMT
Golden-brown High-Protein Pizza Breakfast Casserole with melted mozzarella and cheddar cheese, topped with turkey pepperoni and red onion. Save
Golden-brown High-Protein Pizza Breakfast Casserole with melted mozzarella and cheddar cheese, topped with turkey pepperoni and red onion. | petitskillet.com

Fuel your morning with a High-Protein Pizza Breakfast Casserole that perfectly balances nutrition and flavor. This hearty dish features a unique Greek-yogurt dough base topped with protein-packed eggs, turkey pepperoni, and a blend of melted cheeses. It is an ideal American breakfast choice for those seeking a meal-prep-friendly start to their day that tastes just like your favorite pizza.

Golden-brown High-Protein Pizza Breakfast Casserole with melted mozzarella and cheddar cheese, topped with turkey pepperoni and red onion. Save
Golden-brown High-Protein Pizza Breakfast Casserole with melted mozzarella and cheddar cheese, topped with turkey pepperoni and red onion. | petitskillet.com

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Using a simple self-rising flour and yogurt dough, this casserole offers a satisfying texture without the need for yeast. Whether you are cooking for a family of six or prepping your meals for the week, this easy-to-follow recipe brings a savory twist to the breakfast table.

Ingredients

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  • 1 cup (245 g) plain Greek yogurt (2% or 0% fat)
  • 1 cup (120 g) self-rising flour (plus extra for dusting)
  • 1/2 tsp garlic powder
  • 1/2 tsp dried oregano
  • 1/4 tsp salt
  • 6 large eggs
  • 1/2 cup (120 ml) low-fat milk
  • 1 cup (110 g) shredded mozzarella cheese, part-skim
  • 1/2 cup (50 g) shredded cheddar cheese
  • 1/2 cup (40 g) turkey pepperoni slices
  • 1/2 cup (125 ml) pizza sauce (low-sugar, if preferred)
  • 1/4 cup (25 g) diced bell pepper (optional)
  • 1/4 cup (25 g) diced red onion (optional)
  • 1 tbsp chopped fresh basil or parsley (optional, for garnish)
  • Salt and black pepper, to taste

Instructions

Step 1: Prep
Preheat oven to 400°F (200°C). Lightly grease or line a rimmed 9x13-inch sheet pan with parchment paper.
Step 2: Make the Dough
In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms.
Step 3: Knead
Knead briefly on a lightly floured surface until smooth, about 2–3 minutes.
Step 4: Shape
Roll or press dough into a rectangle to fit your sheet pan. Transfer and press evenly to the edges.
Step 5: Sauce
Spread pizza sauce evenly over the dough base.
Step 6: Whisk Eggs
In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined.
Step 7: First Layer Cheese
Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce.
Step 8: Assemble
Pour the egg mixture evenly over the cheese. Top with turkey pepperoni, remaining cheese, bell pepper, and red onion.
Step 9: Bake
Bake for 22–25 minutes, or until the eggs are set and cheese is golden and bubbly.
Step 10: Serve
Remove from oven. Let cool for 5 minutes, garnish with fresh basil or parsley, then slice and serve warm.

Zusatztipps für die Zubereitung

When working with the Greek yogurt dough, ensure your surface is lightly floured to prevent sticking. Using parchment paper on your 9x13-inch sheet pan will make cleanup much easier and prevent the crust from sticking to the pan during the baking process.

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Varianten und Anpassungen

If you don't have self-rising flour, you can easily substitute it with 1 cup of all-purpose flour mixed with 1 1/2 tsp of baking powder and 1/4 tsp of salt. For those who enjoy a bit of heat, consider adding red pepper flakes to the egg mixture or swapping the turkey pepperoni for spicy turkey sausage.

Serviervorschläge

This pizza-inspired breakfast pairs beautifully with a fresh green salad or a side of seasonal fruit to round out your morning meal. To keep it authentic to the pizza experience, garnish with extra fresh basil or a drizzle of balsamic glaze before serving.

A slice of High-Protein Pizza Breakfast Casserole revealing fluffy baked eggs and turkey pepperoni on a Greek yogurt crust. Save
A slice of High-Protein Pizza Breakfast Casserole revealing fluffy baked eggs and turkey pepperoni on a Greek yogurt crust. | petitskillet.com

Enjoy a nutritious and savory start to your day with this High-Protein Pizza Breakfast Casserole. With 270 calories and 20g of protein per serving, it is a satisfying way to fuel your body for whatever lies ahead.

Recipe Q&A

Can I make this ahead of time?

Yes, you can assemble the entire casserole the night before and refrigerate. When ready to serve, bake as directed, adding a few extra minutes if baking cold.

What can I substitute for self-rising flour?

Mix 1 cup all-purpose flour with 1 1/2 teaspoons baking powder and 1/4 teaspoon salt to create your own self-rising flour substitute.

Is this suitable for freezing?

Absolutely! Once baked and cooled, wrap individual portions or the entire casserole tightly and freeze for up to 3 months. Reheat in the microwave or oven.

Can I use regular pepperoni instead of turkey?

Yes, traditional pepperoni works well. Keep in mind it may be higher in fat and calories compared to the turkey variety.

How do I store leftovers?

Store in an airtight container in the refrigerator for up to 4 days. Reheat in the microwave for 1-2 minutes or in a 350°F oven until warmed through.

Can I add more vegetables?

Definitely! Spinach, mushrooms, diced tomatoes, or bell peppers work wonderfully. Just be sure to cook excess moisture out of vegetables like mushrooms before adding.

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High-Protein Pizza Breakfast Casserole

A protein-packed morning dish with Greek yogurt crust, eggs, pepperoni, and melted cheese. Ready in 45 minutes.

Prep Duration
20 minutes
Cooking Duration
25 minutes
Total Duration
45 minutes
Recipe By Ellis Carlson


Skill Level Easy

Cuisine American

Serves 6 Portions

Diet Info None specified

What You Need

Greek Yogurt Dough

01 1 cup plain Greek yogurt (2% or 0% fat)
02 1 cup self-rising flour, plus extra for dusting
03 1/2 teaspoon garlic powder
04 1/2 teaspoon dried oregano
05 1/4 teaspoon salt

Toppings

01 6 large eggs
02 1/2 cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 1/2 cup shredded cheddar cheese
05 1/2 cup turkey pepperoni slices
06 1/2 cup low-sugar pizza sauce
07 1/4 cup diced bell pepper, optional
08 1/4 cup diced red onion, optional
09 1 tablespoon chopped fresh basil or parsley, optional for garnish
10 Salt and black pepper, to taste

How To Make It

Step 01

Prepare Baking Pan and Preheat Oven: Preheat oven to 400°F. Lightly grease or line a 9x13-inch rimmed sheet pan with parchment paper.

Step 02

Mix and Knead Dough Base: In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms. Knead briefly on a lightly floured surface until smooth, approximately 2-3 minutes.

Step 03

Press Dough into Pan: Roll or press dough into a rectangle to fit the prepared sheet pan. Transfer dough to pan and press evenly to the edges.

Step 04

Apply Pizza Sauce: Spread pizza sauce evenly over the dough base in a uniform layer.

Step 05

Prepare Egg Mixture: In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined.

Step 06

Layer First Cheese Layer: Sprinkle half of the shredded mozzarella and cheddar cheese over the pizza sauce.

Step 07

Pour Egg Custard: Pour the egg mixture evenly over the cheese layer.

Step 08

Add Final Toppings: Top with turkey pepperoni, remaining cheese, bell pepper, and red onion if using.

Step 09

Bake Casserole: Bake for 22-25 minutes, or until the eggs are set and cheese is golden and bubbly.

Step 10

Cool and Serve: Remove from oven and let cool for 5 minutes. Garnish with fresh basil or parsley if desired. Slice and serve warm.

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Equipment Needed

  • Mixing bowls
  • Whisk
  • Rolling pin
  • 9x13-inch sheet pan
  • Parchment paper
  • Knife and cutting board

Allergy Info

Look through each ingredient for allergen concerns, and please ask a medical expert if you've any questions.
  • Contains wheat and gluten
  • Contains eggs
  • Contains milk and dairy products
  • Check pepperoni, cheese, and pizza sauce labels for cross-contamination risks and additional allergens

Nutrition Details (for each serve)

Use these nutrition details as a rough guide—they're not medical advice.
  • Energy: 270
  • Fats: 12 g
  • Carbohydrates: 20 g
  • Proteins: 20 g

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